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Purpose@#To explore and identify priorities of middle-aged couples’ educational needs for psychological well-being. @*Methods@#Exploratory sequential mixed method design was used. Qualitative data were collected from 14 couples through couple interviews and analyzed using interpretative phenomenological analysis. Quantitative data were collected from 234 middle-aged adults using self-administered questionnaires and analyzed using paired t-test and Borichs’ needs assessment model. Finally, qualitative and quantitative data were integrated to describe mixed-method findings. @*Results@#Three major themes were identified: (1) confronting vulnerability to mental health problem, (2) navigating lifes journey together, and (3) progressing toward self-transcendence. In quantitative results, “couple communication” had the highest need, followed by “mental health”, the “emotional awareness and expression”, and “improvement of marital relationships”. Integrated results indicated that couple-communication and mental health were priority needs. @*Conclusion@#Results of this study provided evidence for middle-aged couples educational needs for psychological well-being. Thus, healthcare professionals need to consider development of educational interventions to enhance couple communication and mental health for middle-aged couples psychological well-being.
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Purpose@#The study aimed to translate the Couple Satisfaction Index (CSI 32) into Korean, to evaluate the reliability and validity of CSI 32 and short-form (CSI 16, 4) in the Korean context, and to determine a cut-off score for Korean couples. @*Methods@#Korean Versions of the Couple Satisfaction Index (K-CSI) 32 was translated, back-translated, and reviewed by five bilingual experts. Confirmatory factor analysis (CFA) was conducted with data from a sample of 218 couples (N = 436) to test construct validity. Validity and reliability were evaluated. The receiver’s operating characteristics curve analysis was used to obtain the cut-off score. @*Results@#The construct validities of K-CSI 32, 16, and 4 were verified using one-factor structures. The results of CFA showed a slightly better fit for K-CSI 16 and 4 than for K-CSI 32. Convergent validity was supported by significant positive correlations of K-CSI with Kansas Marital Satisfaction Scale, Dyadic Adjustment Scale, and Family Relationship Assessment Scale. Moreover, the significant differences in K-CSI between normal and depressive group demonstrated known-group validity. Cut-off scores of 105.5 on K-CSI 32, 50.25 on K-CSI 16, and 13.25 on K-CSI 4 were validated to identify distressed couple relationships. @*Conclusion@#For clinical practice, the reliable and valid K-CSI 32 has the potential to measure changes in couple satisfaction after couple therapy or interventions. Applying K-CSI 32 may facilitate research on couple and family relationships in nursing and contribute to the discussion on the role of couple satisfaction in mental health.
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The concept of oligometastasis is widely accepted for various types of solid tumors; accordingly, better outcomes can be anticipated with aggressive local interventions. The treatment of advanced hepatocellular carcinoma (HCC) with extrahepatic metastasis is systemic therapy. However, treatment responses to systemic therapy are poor. Recently, a small number of metastatic cancers (oligometastasis) have been controlled by local therapy rather than systemic therapy. Our study reports a case of a 66-year-old male patient with advanced HCC with lung metastasis, which was treated with local therapy. There were less than four metastases in the lungs, which were treated with wedge resection, radiofrequency, and radiation therapy. He repeatedly underwent local therapy for lung oligometastasis and locoregional therapy for intrahepatic HCC rather than systemic therapy; control by local therapy was possible as his liver function was preserved with Child-Turcotte-Pugh class A.
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Purpose@#The purpose of this study was to translate Duke University Religion Index (DUREL) and the Daily Spiritual Experience Scale (DSES) into Korean and test the validity and reliability of the instruments. @*Methods@#Korean version of DUREL and DSES were translated and back-translated by 6 bilingual experts and group discussions. Data analyses were performed using SPSS 26.0 and AMOS 22.0. Both exploratory and confirmatory factor analyses were conducted with two data sets of secondary analysis study to examine the factor structure and construct validity. Correlations with other variables were used to test validity and reliability. @*Results@#For K-DUREL, the final evaluation yielded two factors with 5 items: intrinsic religiosity and institutional religious activity. K-DSES had two factors with 16 items: transpersonal spiritual experience, and interpersonal & environmental spiritual experience. Cronbach’s ⍺ of K-DUREL and K-DSES were .67 and .96, respectively. Both instruments showed good reliability and validity for the translated Korean versions. @*Conclusion@#Applying K-DUREL and K-DSES in theory-based research may contribute to knowledge about the religious activity and spiritual experiences in the health and well-being of a Korean. Also, two instruments have the potential to measure changes in religion and spirituality after spiritual or holistic nursing interventions.
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Purpose@#The purpose of this study was to translate Duke University Religion Index (DUREL) and the Daily Spiritual Experience Scale (DSES) into Korean and test the validity and reliability of the instruments. @*Methods@#Korean version of DUREL and DSES were translated and back-translated by 6 bilingual experts and group discussions. Data analyses were performed using SPSS 26.0 and AMOS 22.0. Both exploratory and confirmatory factor analyses were conducted with two data sets of secondary analysis study to examine the factor structure and construct validity. Correlations with other variables were used to test validity and reliability. @*Results@#For K-DUREL, the final evaluation yielded two factors with 5 items: intrinsic religiosity and institutional religious activity. K-DSES had two factors with 16 items: transpersonal spiritual experience, and interpersonal & environmental spiritual experience. Cronbach’s ⍺ of K-DUREL and K-DSES were .67 and .96, respectively. Both instruments showed good reliability and validity for the translated Korean versions. @*Conclusion@#Applying K-DUREL and K-DSES in theory-based research may contribute to knowledge about the religious activity and spiritual experiences in the health and well-being of a Korean. Also, two instruments have the potential to measure changes in religion and spirituality after spiritual or holistic nursing interventions.
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Deep learning-based applications have great potential to enhance the quality of medical services. The power of deep learning depends on open databases and innovation. Radiologists can act as important mediators between deep learning and medicine by simultaneously playing pioneering and gatekeeping roles. The application of deep learning technology in medicine is sometimes restricted by ethical or legal issues, including patient privacy and confidentiality, data ownership, and limitations in patient agreement. In this paper, we present an open platform, MI2RLNet, for sharing source code and various pre-trained weights for models to use in downstream tasks, including education, application, and transfer learning, to encourage deep learning research in radiology. In addition, we describe how to use this open platform in the GitHub environment. Our source code and models may contribute to further deep learning research in radiology, which may facilitate applications in medicine and healthcare, especially in medical imaging, in the near future. All code is available at https://github.com/mi2rl/MI2RLNet.
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Extrapontine myelinolysis is a demyelinating disorder usually caused by rapid correction of chronic hyponatremia. We present an 82-year-old female patient with general weakness, and severe hyponatremia (103 mEq/L) which was corrected 14 mEq/L during 21 hours. She was stuporous and presented status epilepticus. Brain T2-weighted image showed high signal intensities of bilateral thalami and electroencephalogram monitoring indicated right hemisphere lateralized periodic discharges, maximal in the right frontal region. This case shows that status epilepticus can occur in a patient of extrapontine myelinolysis involved bilateral thalami without pontine lesions.
Subject(s)
Aged, 80 and over , Female , Humans , Brain , Demyelinating Diseases , Electroencephalography , Hyponatremia , Myelinolysis, Central Pontine , Status Epilepticus , StuporABSTRACT
BACKGROUND: Beta-carotene (BC) is a carotenoid which exerts anti-cancer effects in several types of cancer, including colorectal cancer. Epigenetic modifications of genes, such as histone deacetylation and DNA hypermethylation, have also been detected in various types of cancer. To understand the molecular mechanism underlying cancer preventive and therapeutic effects of BC, microRNAs (miRNAs), histone acetylation, and global DNA methylation in colon cancer stem cells (CSCs) were investigated.METHODS: HCT116 colon cancer cells positive for expression of CD44 and CD133 were sorted by flow cytometry and used in subsequent experiments. Cell proliferation was examined by the MTT assay and self-renewal capacity was analyzed by the sphere formation assay. The miRNA sequencing array was used to detect miRNAs regulated by BC. Histone acetylation levels were measured by the Western blot analysis. mRNA expression of DNA methyltransferases (DNMTs) was examined by qPCR and global DNA methylation levels were determined by enzyme-linked immunosorbent assay.RESULTS: Treatment of CD44⁺CD133⁺ colon CSCs with BC caused a reduction in both cell proliferation and sphere formation. Analysis of the miRNA sequencing array showed that BC regulated expression of miRNAs associated with histone acetylation. Histone H3 and H4 acetylation levels were elevated by BC treatment. In addition, BC treatment down-regulated DNMT3A mRNA expression and global DNA methylation in colon CSCs.CONCLUSIONS: These results suggest that BC regulates epigenetic modifications for its anti-cancer effects in colon CSCs.
Subject(s)
Acetylation , beta Carotene , Blotting, Western , Cell Proliferation , Colon , Colonic Neoplasms , Colorectal Neoplasms , DNA Methylation , DNA , Enzyme-Linked Immunosorbent Assay , Epigenomics , Flow Cytometry , Histones , Methyltransferases , MicroRNAs , RNA, Messenger , Stem Cells , Therapeutic UsesABSTRACT
Paroxysmal dysarthria and ataxia is characterized by abrupt onset of dysarthria and ataxia of unilateral limbs for seconds. We present a 45-year-old female patient with paroxysmal symptoms of dysarthria, right-sided ataxia, and a persistent symptom of upbeating nystagmus. Her brain fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging indicated potential diagnosis of demyelinating disease. The paroxysmal and persistent symptoms have recovered after phenytoin administration. Sodium channel blocker may play a role in reducing the ephaptic transmission in a demyelinated or re-myelinated lesion.